SELECTED PUBLICATIONS 
(by topics)






SELECTED REVIEWS


  • Padmanabhan S, Pérez-Castaño R, Elías-Arnanz M. "B12-based photoreceptors: from structure and function to applications in optogenetics and synthetic biology". Curr. Opin. Struct. Biol. 57: 47-55. DOI: 10.1016/j.sbi.2019.01.020 (2019) 
  • Abstract

  • Elías-Arnanz M, Padmanabhan S, Murillo FJ. "Light-dependent gene regulation in nonphototrophic bacteria". Curr. Opin. Microbiol. 14: 128-135. DOI: 10.1016/j.mib.2010.12.009 (2011)  
  • Abstract

  • Elías-Arnanz M, Padmanabhan S, Murillo FJ. "The regulatory action of the myxobacterial CarD/CarG complex: a bacterial enhanceosome?" FEMS Microbiol. Rev. 34: 764-778. DOI: 10.1111/j.1574-6976.2010.00235.x (2010) 
  • Abstract


SELECTED PAPERS

CarF (plasmanylethanolamine desaturase)

  • Aránzazu Gallego-García , Antonio J. Monera-Girona, Elena Pajares-Martínez, Eva Bastida-Martínez, Ricardo Pérez-Castaño, Antonio A. Iniesta, Marta Fontes, S. Padmanabhan, Montserrat Elías-Arnanz. "A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis". Science 366: 128-132. DOI: 10.1126/science.aay1436  (2019)  (F1000 Prime recommendation)Access the recommendation on F1000Prime
  • Abstract | Reprint | Full text     

  • Galbis-Martínez M, Padmanabhan S, Murillo FJ, Elías-Arnanz M. "CarF mediates signaling by singlet oxygen, generated via photoexcited protoporphyrin IX, in Myxococcus xanthus light-induced carotenogenesis". J. Bacteriol. 194: 1427-1436. DOI: 10.1128/JB.06662-11 
  • Abstract

  • Fontes M, Galbis-Martínez L, Murillo FJ. "A novel regulatory gene for light-induced carotenoid synthesis in the bacterium Myxococcus xanthus". Mol. Microbiol. 47: 561-571. DOI: 10.1046/j.1365-2958.2003.03319.x (2003) 
  • Abstract


CarH & B12-dependent photoreceptors

  • Ortiz-Guerrero JM, Polanco MC, Murillo FJ, Padmanabhan S, Elías-Arnanz M. "Light-dependent gene regulation by a coenzyme B12-based photoreceptor." Proc. Natl. Acad. Sci. USA. 108: 7565-7570. DOI: 10.1073/pnas.1018972108 (2011) (Highlighted in: Sci. Signal. 4: ec131 (2011); Mol Microbiol 91: 635 (2014); Cell 163: 1295 (2015); Angew. Chem. 55: 2 (2016)) 
  • Abstract

  • Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL. "Structural basis for gene regulation by a B12-dependent photoreceptor". Nature 526: 536-541. DOI: 10.1038/nature14950 (2015) (Highlighted in: Cell 163: 1295 (2015); Angew. Chem. 55: 2 (2016); C & En. News, p. 27, Oct. 16, 2015) 
  • Abstract

  • Kutta RJ, Hardman SJO, Johannissen LO, Bellina B, Messiha HL, Ortiz-Guerrero JM, Elías-Arnanz M, Padmanabhan S, Barran P, Scrutton NS, Jones AR. "The photochemical mechanism of a B12-dependent photoreceptor protein". Nat. Commun. 6: 7907. DOI: 10.1038/ncomms8907 (2015) (Highlighted in: Cell 163: 1295 (2015); Angew. Chem. 55: 2 (2016)) 
  • Abstract

  • Pérez-Marín MC, Padmanabhan S, Polanco MC, Murillo FJ, Elías-Arnanz M. "Vitamin B12 partners the CarH repressor to downregulate a photoinducible promoter in Myxococcus xanthus". Mol. Microbiol. 67: 804-819. DOI: 10.1111/j.1365-2958.2007.06086.x (2008) 
  • Abstract

  • Fernández-Zapata J, Pérez-Castaño R, Aranda J, Colizzi F, Polanco MC, Orozco M, Padmanabhan S, Elías-Arnanz M. "Plasticity in oligomerization, operator architecture, and DNA binding in the mode of action of a bacterial B12-based photoreceptor". J. Biol. Chem. 293: 17888-17905. DOI: 10.1074/jbc.RA118.004838 (2018) 
  • Abstract 

CarA repressor & CarS antirepressor

  • León E, Navarro-Avilés G, Santiveri CM, Flores-Flores C, Rico M, González C, Murillo FJ, Elías-Arnanz M, Jiménez MA, Padmanabhan S. "A bacterial antirepressor with SH3 domain topology mimics operator DNA in sequestering the repressor DNA recognition helix". Nucleic Acids Res. 38: 5226-5241. DOI: 10.1093/nar/gkq277 (2010) (F1000 Prime recommendation) 
  • Abstract

  • Navarro-Avilés G, Jiménez MA, Pérez-Marín MC, González C, Rico M, Murillo FJ, Elías-Arnanz M, Padmanabhan S. "Structural basis for operator and antirepressor recognition by Myxococcus xanthus CarA repressor". Mol. Microbiol. 63: 980-994. DOI: 10.1111/j.1365-2958.2006.05567.x (2007) 
  • Abstract
 
  • López-Rubio JJ, Elías-Arnanz M, Padmanabhan S, Murillo FJ. "A repressor-antirepressor pair links two loci controlling light-induced carotenogenesis in Myxococcus xanthus". J. Biol. Chem. 277: 7262-7270. DOI: 10.1074/jbc.M110351200 (2002) 
  • Abstract

  • López-Rubio JJ, Padmanabhan S, Lázaro JM, Salas M, Murillo FJ, Elías-Arnanz M. "Operator design and mechanism for CarA repressor-mediated down-regulation of the photoinducible carB operon in Myxococcus xanthus". J. Biol. Chem. 279: 28945-28953. DOI: 10.1074/jbc.M403459200 (2004) 
  • Abstract

CarD and CarG global regulators

  • Peñalver-Mellado M, García-Heras F, Padmanabhan S, García-Moreno D, Murillo FJ, Elías-Arnanz M. "Recruitment of a novel zinc-bound transcriptional factor by a bacterial HMGA-type protein is required for regulating multiple processes in Myxococcus xanthus". Mol. Microbiol. 61: 910-926. DOI: 10.1111/j.1365-2958.2006.05289.x (2006) 
  • Abstract

  • García-Heras F, Padmanabhan S, Murillo FJ, Elías-Arnanz M. "Functional equivalence of HMGA- and histone H1-like domains in a bacterial transcriptional factor". Proc. Natl. Acad. Sci USA 106: 13546-13551. DOI: 10.1073/pnas.0902233106 (2009) 
  • Abstract

  • Padmanabhan S, Elías-Arnanz M, Carpio E, Aparicio P, Murillo FJ. "Domain architecture of a high mobility group A-type bacterial transcriptional factor". J. Biol. Chem. 276: 41566-41575. DOI: 10.1074/jbc.M106352200 (2001) 
  • Abstract

  • Nicolas FJ, Cayuela ML, Martínez-Argudo IM, Ruiz-Vazquez RM, Murillo FJ. "High mobility group I(Y)-like DNA-binding domains on a bacterial transcription factor". Proc. Natl. Acad. Sci. USA 93: 6881-6885. DOI: 10.1073/pnas.93.14.6881 (1996) 
  • Abstract

  • Abellón-Ruiz J, Bernal-Bernal D, Abellán M, Fontes M, Padmanabhan S, Murillo FJ, Elías-Arnanz M. "The CarD/CarG regulatory complex is required for the action of several members of the large set of Myxococcus xanthus extracytoplasmic function σ factors". Environ. Microbiol. 16: 2475-2490. DOI: 10.1111/1462-2920.12386 (2014) 
  • Abstract

  • Cayuela ML, Elías-Arnanz M, Peñalver-Mellado M, Padmanabhan S, Murillo FJ. "The Stigmatella aurantiaca homolog of Myxococcus xanthus high-mobility-group A-type transcription factor CarD: insights into the functional modules of CarD and their distribution in bacteria". J. Bacteriol. 185: 3527-3537.  DOI: 10.1128/jb.185.12.3527-3537.2003 (2003) 
  • Abstract

  • Galbis-Martínez M, Fontes M, Murillo FJ. "The high-mobility group A-type protein CarD of the bacterium Myxococcus xanthus as a transcription factor for several distinct vegetative genes". Genetics 167: 1585-1595. DOI: 10.1534/genetics.104.029207 (2004) 
  • Abstract

  • Nicolás FJ, Ruiz-Vázquez RM, Murillo FJ. "A genetic link between light response and multicellular development in the bacterium Myxococcus xanthus". Genes Dev. 8: 2375-2387.DOI: 10.1101/gad.8.19.2375 (1994) 
  • Abstract

Myxococcus xanthus CRISPR-Cas Systems

  • Bernal-Bernal D, Abellón-Ruiz J, Iniesta AA, Pajares-Martínez E, Bastida-Martínez E, Fontes M, Padmanabhan S, Elías-Arnanz M. "Multifactorial control of the expression of a CRISPR-Cas system by an extracytoplasmic function σ/anti-σ pair and a global regulatory complex". Nucleic Acids Res. 46: 6726-6745. DOI: 10.1093/nar/gky475 (2019) 
  • Abstract


CdnL global regulator

  • García-Moreno D, Abellón-Ruiz J, García-Heras F, Murillo FJ, Padmanabhan S, Elías-Arnanz M. "CdnL, a member of the large CarD-like family of bacterial proteins, is vital for Myxococcus xanthus and differs functionally from the global transcriptional regulator CarD". Nucleic Acids Res. 38: 4586-4598. DOI: 10.1093/nar/gkq214 (2009) 
  • Abstract

  • Gallego-García A, Mirassou Y, García-Moreno D, Elías-Arnanz M, Jiménez MA, Padmanabhan S. "Structural insights into RNA polymerase recognition and essential function of Myxococcus xanthus CdnL". PLoS One 9: e108946. DOI: 10.1371/journal.pone.0108946 (2014) 
  • Abstract

  • Gallego-García A, Iniesta AA, González D, Collier J, Padmanabhan S, Elías-Arnanz M. "Caulobacter crescentus CdnL is a non-essential RNA polymerase-binding protein whose depletion impairs normal growth and rRNA transcription". Sci. Rep. 7: 43240. DOI: 10.1038/srep43240 (2017) 
  • Abstract

Inducible systems for conditional expression in M. xanthus

  • Iniesta AA, García-Heras F, Abellón-Ruiz J, Gallego-García A, Elías-Arnanz M. "Two systems for conditional gene expression in Myxococcus xanthus inducible by isopropyl-β-D-thiogalactopyranoside or vanillate". J. Bacteriol. 194: 5875-5885. DOI: 10.1128/JB.01110-12 (2012)  
  • Abstract

  • García-Moreno D, Polanco MC, Navarro-Avilés G, Murillo FJ, Padmanabhan S, Elías-Arnanz M. "A vitamin B12-based system for conditional expression reveals dksA to be an essential gene in Myxococcus xanthus". J. Bacteriol. 191: 3108-3119. DOI: 10.1128/JB.01737-08 (2009) 
  • Abstract


Light-induced carotenogenesis in M. xanthus (earliest studies)

  • Balsalobre JM, Ruiz-Vazquez RM, Murillo FJ. "Light induction of gene expression in Myxococcus xanthus". Proc. Natl. Acad. Sci. USA 84: 2359-2362. DOI: 10.1073/pnas.84.8.2359 (1987) 
  • Abstract

  • Ruiz-Vázquez R, Fontes M, Murillo FJ. "Clustering and co-ordinated activation of carotenoid genes in Myxococcus xanthus by blue light". Mol. Microbiol. 10: 25-34. DOI: 10.1111/j.1365-2958.1993.tb00900.x (1993) 
  • Abstract

  • Botella JA, Murillo FJ, Ruiz-Vázquez R. "A cluster of structural and regulatory genes for light-induced carotenogenesis in Myxococcus xanthus". Eur. J. Biochem. 233: 238-248. DOI: 10.1111/j.1432-1033.1995.238_1.x (1995) 
  • Abstract

  • Fontes M, Ruiz-Vázquez R, Murillo FJ. "Growth phase dependence of the activation of a bacterial gene for carotenoid synthesis by blue light". EMBO J. 12: 1265-1275. DOI: 10.1002/j.1460-2075.1993.tb05771.x (1993) 
  • Abstract



Copper-induced carotenogenesis in M. xanthus
  • Moraleda-Muñoz A, Pérez J, Fontes M, Murillo FJ, Muñoz-Dorado J. "Copper induction of carotenoid synthesis in the bacterium Myxococcus xanthus". Mol. Microbiol. 56: 1159-1168. DOI: 10.1111/j.1365-2958.2005.04613.x (2005) 
  • Abstract



Germination in M. xanthus