PUBLICATIONS 
 
MYXO Papers & Reviews

2024

Arroyo AB, Tyrkalska SD, Bastida-Martínez E, Monera-Girona AJ, Cantón-Sandoval J, Bernal-Carrión M, García-Moreno D, Elías-Arnanz M, Mulero V. “Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation” Cell Death Discov. 10(1): 388. DOI: 10.1038/s41420-024-02141-w

Pérez-Castaño R, Aranda J, Widner FJ, Kieninger C, Deery E, Warren MJ, Orozco M, Elías-Arnanz M, Padmanabhan S, Kräutler B. “The Rhodium Analogue of Coenzyme B12 as an Anti-Photoregulatory Ligand Inhibiting Bacterial CarH Photoreceptors” Angew Chem Int Ed Engl. 63(18): e202401626. DOI: 10.1002/anie.202401626

2023

López-Rojo A, Jackson SA, Bernal-Bernal D, Galbis-Martínez M, Fineran PC, Elías-Arnanz M. “Genome sequences of Mx1, the first Myxococcus phage isolated, and Mx4, a generalized transducing myxophage” Microbiol Resour Announc. 12(12): e0090423. DOI: 10.1128/MRA.00904-23

López-Rojo A, Bernal-Bernal D, Padmanabhan S, Galbis-Martínez ML, Elías-Arnanz M. “Complete Genome Sequence Assembly and Annotation for Myxococcus xanthus Strains DK1050 and DK101” Microbiol Resour Announc. 12(3): e0102022. DOI: 10.1128/mra.01020-22

2022

Padmanabhan S, Monera-Girona AJ, Pajares-Martínez E, Bastida-Martínez E, del Rey Navalón I, Pérez-Castaño R, Galbis-Martínez ML, Fontes M, Elías-Arnanz M. “Plasmalogens and photooxidative stress signaling in myxobacteria, and how it unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for human plasmalogen biosynthesis” Frontiers in Cell and Developmental Biology, 10: 884689. DOI: 10.3389/fcell.2022.884689

Padmanabhan S, Pérez-Castaño R, Osete-Alcaraz L, Polanco MC, Elías-Arnanz M. “Vitamin B12 Photoreceptors” in Vitamin B12, 1st Edition - March 24, 2022, (Editor: Gerald Litwack) Volume 119 in Vitamins and Hormones book series is published online. https://doi.org/10.1016/bs.vh.2022.01.007.

Pérez-Castaño R, Bastida-Martínez E, Fernández Zapata J, Polanco MDC, Galbis-Martínez ML, Iniesta AA, Fontes M, Padmanabhan S, Elías-Arnanz M. “Coenzyme B12-dependent and independent photoregulation of carotenogenesis across Myxococcales” Environmental Microbiology  24: 1865-1886. DOI: 10.1111/1462-2920.15895

 
2021

Padmanabhan S, Monera-Girona AJ, Pérez-Castaño R, Bastida-Martínez E, Pajares-Martínez E, Bernal-Bernal D, Galbis-Martínez ML, Polanco MC, Iniesta AA, Fontes M, Elías-Arnanz M. “Light-triggered carotenogenesis in Myxococcus xanthus: New paradigms in photosensory signaling, transduction and gene regulation” Microorganisms 9: 1067. DOI:  10.3390/microorganisms9051067
 
2020

Miller NA, Kaneshiro AK, Konar A, Alonso-Mori R, Britz A, Deb A, Glownia JM, Koralek JD, Mallik L, Meadows JH, Michocki LB, van Driel TB, Koutmos M, Padmanabhan S, Elías-Arnanz M, Kubarych KJ, Marsh ENG, Penner-Hahn JE, Sension RJ . “The photoactive excited state of the B12-based photoreceptor CarH” J Phys Chem B 124: 10732-10738. DOI: 10.1021/acs.jpcb.0c09428
 
Elías-Arnanz M. "Anaerobic bacteria need their vitamin B12 to digest estrogen". Proc. Natl. Acad. Sci. USA. 117: 1833-1835. DOI: 10.1073/pnas.1921340117
 
2019

Gallego-García A, Monera-Girona AJ, Pajares-Martínez E, Bastida-Martínez E, Pérez-Castaño R, Iniesta AA, Fontes M, Padmanabhan S, Elías-Arnanz M. "A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis". Science 366: 128-132. DOI: 10.1126/science.aay1436
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 Padmanabhan S, Pérez-Castaño R, Elías-Arnanz M. "B12-based photoreceptors: from structure and function to applications in optogenetics and synthetic biology". Curr. Opin. Struct. Biol. 57: 47-55. DOI: 10.1016/j.sbi.2019.01.020

2018

Fernández-Zapata J, Pérez-Castaño R, Aranda J, Colizzi F, Polanco MC, Orozco M, Padmanabhan S, Elías-Arnanz M. "Plasticity in oligomerization, operator architecture, and DNA binding in the mode of action of a bacterial B12-based photoreceptor". J. Biol. Chem. 293: 17888-17905. DOI: 10.1074/jbc.RA118.004838

Bernal-Bernal D, Abellón-Ruiz J, Iniesta AA, Pajares-Martínez E, Bastida-Martínez E, Fontes M, Padmanabhan S, Elías-Arnanz M. "Multifactorial control of the expression of a CRISPR-Cas system by an extracytoplasmic function σ/anti-σ pair and a global regulatory complex". Nucleic Acids Res. 46: 6726-6745. DOI: 10.1093/nar/gky475

2017

Padmanabhan S, Jost M, Drennan CL, Elías-Arnanz M. "A new facet of vitamin B12: Gene regulation by cobalamin-based photoreceptors". Annu Rev Biochem. 86: 485-514. DOI: 10.1146/annurev-biochem-061516-044500

Gallego-García A, Iniesta AA, González D, Collier J, Padmanabhan S, Elías-Arnanz M. "Caulobacter crescentus CdnL is a non-essential RNA polymerase-binding protein whose depletion impairs normal growth and rRNA transcription". Sci. Rep. 7: 43240. DOI: 10.1038/srep43240

2015

Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL. "Structural basis for gene regulation by a B12-dependent photoreceptor". Nature 526: 536-541. DOI: 10.1038/nature14950

(Highlighted in: Cell 163: 1295 (2015); Angew. Chem. 55: 2 (2016); C & En. News, p. 27, Oct. 16, 2015)
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Kutta RJ, Hardman SJO, Johannissen LO, Bellina B, Messiha HL, Ortiz-Guerrero JM, Elías-Arnanz M, Padmanabhan S, Barran P, Scrutton NS, Jones AR. "The photochemical mechanism of a B12-dependent photoreceptor protein". Nat. Commun. 6: 7907. DOI: 10.1038/ncomms8907  
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Bernal-Bernal D, Gallego-García A, García-Martínez G, García-Heras F, Jiménez MA, Padmanabhan S, Elías-Arnanz M. "Structure-function dissection of Myxococcus xanthus CarD N-terminal domain, a defining member of the CarD_CdnL_TRCF family of RNA polymerase interacting proteins". PLoS One. 10: e0121322. DOI: 10.1371/journal.pone.0121322

2014

Iniesta AA. "ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus". PLoS One. 9: e86897. DOI: 10.1371/journal.pone.0086897

Gallego-García A, Mirassou Y, García-Moreno D, Elías-Arnanz M, Jiménez MA, Padmanabhan S. "Structural insights into RNA polymerase recognition and essential function of Myxococcus xanthus CdnL". PLoS One 9: e108946. DOI: 10.1371/journal.pone.0108946

Abellón-Ruiz J, Bernal-Bernal D, Abellán M, Fontes M, Padmanabhan S, Murillo FJ, Elías-Arnanz M. "The CarD/CarG regulatory complex is required for the action of several members of the large set of Myxococcus xanthus extracytoplasmic function σ factors". Environ. Microbiol. 16: 2475-2490. DOI: 10.1111/1462-2920.12386

2013

Díez AI, Ortiz-Guerrero JM, Ortega A, Elías-Arnanz M, Padmanabhan S, García de la Torre J. "Analytical ultracentrifugation studies of oligomerization and DNA-binding of TtCarH, a Thermus thermophilus coenzyme B12-based photosensory regulator". Eur. Biophys. J. 42: 463-476. DOI: 10.1007/s00249-013-0897-x

Mirassou Y, Elías-Arnanz M, Padmanabhan S, Jiménez MA. 1H, 13C and 15N assignments of CdnL, an essential protein in Myxococcus xanthus". Biomol. NMR Assign. 7: 51-55. DOI: 10.1007/s12104-012-9375-0

García-Heras F, Abellón-Ruiz J, Murillo FJ, Padmanabhan S, Elías-Arnanz M. "High-mobility-group A-like CarD binds to a DNA site optimized for affinity and position and to RNA polymerase to regulate a light-inducible promoter in Myxococcus xanthus". J. Bacteriol. 195: 378-388.DOI: 10.1128/JB.01766-12

2012

Iniesta AA, García-Heras F, Abellón-Ruiz J, Gallego-García A, Elías-Arnanz M. "Two systems for conditional gene expression in Myxococcus xanthus inducible by isopropyl-β-D-thiogalactopyranoside or vanillate". J. Bacteriol. 194: 5875-5885. DOI: 10.1128/JB.01110-12

Gallego-García A, Mirassou Y, Elías-Arnanz M, Padmanabhan S, Jiménez MA. NMR structure note: N-terminal domain of Thermus thermophilus CdnL. J. Biomol. NMR. 53: 355-363. DOI: 10.1007/s10858-012-9648-z

Galbis-Martínez M, Padmanabhan S, Murillo FJ, Elías-Arnanz M. "CarF mediates signaling by singlet oxygen, generated via photoexcited protoporphyrin IX, in Myxococcus xanthus light-induced carotenogenesis". J. Bacteriol. 194: 1427-1436. DOI: 10.1128/JB.06662-11

2011

Ortiz-Guerrero JM, Polanco MC, Murillo FJ, Padmanabhan S, Elías-Arnanz M. "Light-dependent gene regulation by a coenzyme B12-based photoreceptor." Proc. Natl. Acad. Sci. USA. 108: 7565-7570. DOI: 10.1073/pnas.1018972108 
(Highlighted in: Sci. Signal. 4: ec131 (2011); Mol Microbiol 91: 635 (2014); Cell 163: 1295 (2015); Angew. Chem. 55: 2 (2016))
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Elías-Arnanz M, Padmanabhan S, Murillo FJ. "Light-dependent gene regulation in nonphototrophic bacteria". Curr. Opin. Microbiol. 14: 128-135. DOI: 10.1016/j.mib.2010.12.009

2010

Elías-Arnanz M, Padmanabhan S, Murillo FJ. "The regulatory action of the myxobacterial CarD/CarG complex: a bacterial enhanceosome?" FEMS Microbiol. Rev. 34: 764-778. DOI: 10.1111/j.1574-6976.2010.00235.x

León E, Navarro-Avilés G, Santiveri CM, Flores-Flores C, Rico M, González C, Murillo FJ, Elías-Arnanz M, Jiménez MA, Padmanabhan S. "A bacterial antirepressor with SH3 domain topology mimics operator DNA in sequestering the repressor DNA recognition helix". Nucleic Acids Res. 38: 5226-5241. DOI: 10.1093/nar/gkq277  
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García-Moreno D, Abellón-Ruiz J, García-Heras F, Murillo FJ, Padmanabhan S, Elías-Arnanz M. "CdnL, a member of the large CarD-like family of bacterial proteins, is vital for Myxococcus xanthus and differs functionally from the global transcriptional regulator CarD". Nucleic Acids Res. 38: 4586-4598. DOI: 10.1093/nar/gkq214

2009

García-Heras F, Padmanabhan S, Murillo FJ, Elías-Arnanz M. "Functional equivalence of HMGA- and histone H1-like domains in a bacterial transcriptional factor". Proc. Natl. Acad. Sci USA 106: 13546-13551. DOI: 10.1073/pnas.0902233106

León E, González C, Elías-Arnanz M, Padmanabhan S, Jiménez MA. "1H, 13C and 15N backbone and side chain resonance assignments of a Myxococcus xanthus anti-repressor with no known sequence homologues". Biomol. NMR Assign. 3: 37-40. DOI: 10.1007/s12104-008-9136-2

Mirassou Y, García-Moreno D, Santiveri CM, Santoro J, Elías-Arnanz M, Padmanabhan S, Jiménez MA. "1H, 13C and 15N backbone and side chain resonance assignments of the C-terminal domain of CdnL from Myxococcus xanthus". Biomol. NMR Assign. 3: 9-12. DOI: 10.1007/s12104-008-9128-2

García-Moreno D, Polanco MC, Navarro-Avilés G, Murillo FJ, Padmanabhan S, Elías-Arnanz M. "A vitamin B12-based system for conditional expression reveals dksA to be an essential gene in Myxococcus xanthus". J. Bacteriol. 191: 3108-3119. DOI: 10.1128/JB.01737-08

2008

Pérez-Marín MC, Padmanabhan S, Polanco MC, Murillo FJ, Elías-Arnanz M. "Vitamin B12 partners the CarH repressor to downregulate a photoinducible promoter in Myxococcus xanthus". Mol. Microbiol. 67: 804-819. DOI: 10.1111/j.1365-2958.2007.06086.x

Galbis-Martínez L, Galbis-Martínez M, Murillo FJ, Fontes M. "An anti-antisigma factor in the response of the bacterium Myxococcus xanthus to blue light". Microbiology 154: 895-904. doi: 10.1099/mic.0.2007/013359-0. DOI: 10.1099/mic.0.2007/013359-0

Iniesta AA, Cervantes M, Murillo FJ. "Conversion of the lycopene monocyclase of Myxococcus xanthus into a bicyclase". Appl. Microbiol. Biotechnol. 79: 793-802. doi: 10.1007/s00253-008-1481-7. DOI: 10.1007/s00253-008-1481-7

2007

Navarro-Avilés G, Jiménez MA, Pérez-Marín MC, González C, Rico M, Murillo FJ, Elías-Arnanz M, Padmanabhan S. "Structural basis for operator and antirepressor recognition by Myxococcus xanthus CarA repressor". Mol. Microbiol. 63: 980-994. DOI: 10.1111/j.1365-2958.2006.05567.x

Iniesta AA, Cervantes M, Murillo FJ. "Cooperation of two carotene desaturases in the production of lycopene in Myxococcus xanthus". FEBS J. 274: 4306-4314.
DOI: 10.1111/j.1742-4658.2007.05960.x

2006

Peñalver-Mellado M, García-Heras F, Padmanabhan S, García-Moreno D, Murillo FJ, Elías-Arnanz M. "Recruitment of a novel zinc-bound transcriptional factor by a bacterial HMGA-type protein is required for regulating multiple processes in Myxococcus xanthus". Mol. Microbiol. 61: 910-926. DOI: 10.1111/j.1365-2958.2006.05289.x

2005

Moraleda-Muñoz A, Pérez J, Fontes M, Murillo FJ, Muñoz-Dorado J. "Copper induction of carotenoid synthesis in the bacterium Myxococcus xanthus". Mol. Microbiol. 56: 1159-1168. DOI: 10.1111/j.1365-2958.2005.04613.x

2004

Pérez-Marín MC, López-Rubio JJ, Murillo FJ, Elías-Arnanz M, Padmanabhan S. "The N-terminus of Myxococcus xanthus CarA repressor is an autonomously folding domain that mediates physical and functional interactions with both operator DNA and antirepressor protein". J. Biol. Chem. 279: 33093-33103. DOI: 10.1074/jbc.M405225200

López-Rubio JJ, Padmanabhan S, Lázaro JM, Salas M, Murillo FJ, Elías-Arnanz M. "Operator design and mechanism for CarA repressor-mediated down-regulation of the photoinducible carB operon in Myxococcus xanthus". J. Biol. Chem. 279: 28945-28953. DOI: 10.1074/jbc.M403459200

Galbis-Martínez M, Fontes M, Murillo FJ. "The high-mobility group A-type protein CarD of the bacterium Myxococcus xanthus as a transcription factor for several distinct vegetative genes". Genetics 167: 1585-1595. DOI: 10.1534/genetics.104.029207

2003

Fontes M, Galbis-Martínez L, Murillo FJ. "A novel regulatory gene for light-induced carotenoid synthesis in the bacterium Myxococcus xanthus". Mol. Microbiol. 47: 561-571. DOI: 10.1046/j.1365-2958.2003.03319.x

Cayuela ML, Elías-Arnanz M, Peñalver-Mellado M, Padmanabhan S, Murillo FJ. "The Stigmatella aurantiaca homolog of Myxococcus xanthus high-mobility-group A-type transcription factor CarD: insights into the functional modules of CarD and their distribution in bacteria". J. Bacteriol. 185: 3527-3537.  DOI: 10.1128/jb.185.12.3527-3537.2003

2002

López-Rubio JJ, Elías-Arnanz M, Padmanabhan S, Murillo FJ. "A repressor-antirepressor pair links two loci controlling light-induced carotenogenesis in Myxococcus xanthus". J. Biol. Chem. 277: 7262-7270. DOI: 10.1074/jbc.M110351200

Cervantes M, Murillo FJ. "Role for vitamin B12 in light induction of gene expression in the bacterium Myxococcus xanthus". J. Bacteriol. 184: 2215-2224. DOI: 10.1128/jb.184.8.2215-2224.2002

2001

Moreno AJ, Fontes M, Murillo FJ. "ihfA gene of the bacterium Myxococcus xanthus and its role in activation of carotenoid genes by blue light". J. Bacteriol. 183: 557-569. DOI: 10.1128/JB.183.2.557-569.2001

Padmanabhan S, Elías-Arnanz M, Carpio E, Aparicio P, Murillo FJ. "Domain architecture of a high mobility group A-type bacterial transcriptional factor". J. Biol. Chem. 276: 41566-41575. DOI: 10.1074/jbc.M106352200

1998

Martínez-Argudo I, Ruiz-Vázquez RM, Murillo FJ. "The structure of an ECF-sigma-dependent, light-inducible promoter from the bacterium Myxococcus xanthus". Mol. Microbiol. 30: 883-893. DOI: 10.1046/j.1365-2958.1998.01129.x

1996

Nicolas FJ, Cayuela ML, Martínez-Argudo IM, Ruiz-Vazquez RM, Murillo FJ. "High mobility group I(Y)-like DNA-binding domains on a bacterial transcription factor". Proc. Natl. Acad. Sci. USA 93: 6881-6885. DOI: 10.1073/pnas.93.14.6881

1995

Botella JA, Murillo FJ, Ruiz-Vázquez R. "A cluster of structural and regulatory genes for light-induced carotenogenesis in Myxococcus xanthus". Eur. J. Biochem. 233: 238-248. DOI: 10.1111/j.1432-1033.1995.238_1.x

1994

Nicolás FJ, Ruiz-Vázquez RM, Murillo FJ. "A genetic link between light response and multicellular development in the bacterium Myxococcus xanthus". Genes Dev. 8: 2375-2387.DOI: 10.1101/gad.8.19.2375

1993

Ruiz-Vázquez R, Fontes M, Murillo FJ. "Clustering and co-ordinated activation of carotenoid genes in Myxococcus xanthus by blue light". Mol. Microbiol. 10: 25-34. DOI: 10.1111/j.1365-2958.1993.tb00900.x

Fontes M, Ruiz-Vázquez R, Murillo FJ. "Growth phase dependence of the activation of a bacterial gene for carotenoid synthesis by blue light". EMBO J. 12: 1265-1275. DOI: 10.1002/j.1460-2075.1993.tb05771.x

1991

Elías M, Murillo FJ. "Induction of germination in Myxococcus xanthus fruiting body spores". J. Gen. Microbiol. 137: 381-388. DOI: 10.1099/00221287-137-2-381

Elías M, Murillo FJ. "Mutations affecting germination in Myxococcus xanthus".  J. Gen. Microbiol. 137: 389-397. DOI: 10.1099/00221287-137-2-389

1990

Martínez-Laborda A, Balsalobre JM, Fontes M, Murillo FJ. "Accumulation of carotenoids in structural and regulatory mutants of the bacterium Myxococcus xanthus". Mol. Gen. Genet. 223: 205-210. DOI: 10.1007/bf00265055

1989

Martinez-Laborda A, Murillo FJ. "Genic and allelic interactions in the carotenogenic response of Myxococcus xanthus to blue light". Genetics 122: 481-490. PMCID: PMC1203723

1987

Balsalobre JM, Ruiz-Vazquez RM, Murillo FJ. "Light induction of gene expression in Myxococcus xanthus". Proc. Natl. Acad. Sci. USA 84: 2359-2362. DOI:
10.1073/pnas.84.8.2359

1986

Martínez-Laborda A, Elías M, Ruiz-Vázquez R, Murillo FJ. "Insertions of Tn5 linked to mutations affecting carotenoid synthesis in Myxococcus xanthus". Mol. Gen. Genet. 205: 107-114. DOI: 10.1007/bf02428039